Amiodarone and risk of liver cirrhosis: a nationwide, population-based study
CH Huang, YY Lai, YJ Kuo, SC Yang… - … and Clinical Risk …, 2019 - Taylor & Francis
CH Huang, YY Lai, YJ Kuo, SC Yang, YJ Chang, KK Chang, WK Chen
Therapeutics and Clinical Risk Management, 2019•Taylor & FrancisBackground Liver cirrhosis is an uncommon but not rare side effect of amiodarone-induced
hepatotoxicity. Patients with hepatitis B virus and hepatitis C virus infections are at a high
risk for developing liver cirrhosis. However, the relationship between this treatment and risk
of liver cirrhosis in high-risk chronic hepatitis B and chronic hepatitis C patients is unknown.
Patients and methods The present study identified amiodarone users (N= 8,081) from the
Taiwan National Health Insurance Research Database from 1997 through 2013. A total of …
hepatotoxicity. Patients with hepatitis B virus and hepatitis C virus infections are at a high
risk for developing liver cirrhosis. However, the relationship between this treatment and risk
of liver cirrhosis in high-risk chronic hepatitis B and chronic hepatitis C patients is unknown.
Patients and methods The present study identified amiodarone users (N= 8,081) from the
Taiwan National Health Insurance Research Database from 1997 through 2013. A total of …
Background
Liver cirrhosis is an uncommon but not rare side effect of amiodarone-induced hepatotoxicity. Patients with hepatitis B virus and hepatitis C virus infections are at a high risk for developing liver cirrhosis. However, the relationship between this treatment and risk of liver cirrhosis in high-risk chronic hepatitis B and chronic hepatitis C patients is unknown.
Patients and methods
The present study identified amiodarone users (N=8,081) from the Taiwan National Health Insurance Research Database from 1997 through 2013. A total of 32,324 subjects with age, comorbidities, gender, and index date-matched non-amiodarone users were selected as controls (non-amiodarone cohort). The incidences of cumulative liver cirrhosis were compared between cohorts. Stratified Cox’s regression hazard models were used to assess possible comorbidity-attributable risks for liver cirrhosis.
Results
The amiodarone cohort had a nonsignificant risk of liver cirrhosis compared with the non-amiodarone cohort, with a HR of 1.17 (95% CI: 0.93–1.47; P=0.1723). Patients with specific comorbid diseases, including type 2 diabetes mellitus, chronic hepatitis B, chronic hepatitis C, and heart failure, were probably at a high risk of developing liver cirrhosis. The use of statins was associated with a significant 42% reduction in the risk of liver cirrhosis.
Conclusion
Patients in the amiodarone cohort had no excess risk of liver cirrhosis compared with patients in the non-amiodarone cohort. Long-term surveillance for liver toxicity in high-risk patients with amiodarone treatment is suggested.
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